Rx Prescription Only
PABTOP-DSR
CapsulesPantoprazole Gastro-Resistant & Domperidone Prolonged-Release Capsules IP
PABTOP-DSR is a prescription combination capsule containing Pantoprazole Sodium 40 mg (as gastro-resistant pellets) and Domperidone 30 mg (as prolonged-release pellets). This dual-action formulation is widely prescribed for the management of acid-related gastrointestinal disorders, offering both acid suppression and improved...
Pack Size
10×10 Capsules
Marketed By
Pab Pharma
Type
Prescription Medicine
Form
Hard Gelatin Prolonged-Release Capsules
Clinical Overview
PABTOP-DSR is a prescription combination capsule containing Pantoprazole Sodium 40 mg (as gastro-resistant pellets) and Domperidone 30 mg (as prolonged-release pellets). This dual-action formulation is widely prescribed for the management of acid-related gastrointestinal disorders, offering both acid suppression and improved gastric motility in a single, convenient once-daily capsule. The "DSR" (Delayed-release Sustained-Release) technology in PABTOP-DSR ensures that both active ingredients are released at the right time and place in the digestive tract — Pantoprazole is protected from stomach acid and absorbed in the intestine, while Domperidone is released gradually for sustained prokinetic effect.Composition
| Ingredient | Strength | Class |
|---|---|---|
| Pantoprazole Sodium IP | 40 mg | As Gastro-resistant pellets |
| Domperidone IP | 30 mg | As Prolonged-release pellets |
| Excipients | q.s. | — |
What Is PABTOP-DSR Used For?
PABTOP-DSR is primarily used for the treatment and management of:
- PABTOP-DSR is prescribed for the treatment and management of:
- Gastroesophageal Reflux Disease (GERD) — Chronic acid reflux causing heartburn, chest discomfort, and regurgitation
- Acid Peptic Disease — Excess stomach acid causing pain, burning, and ulcers
- Peptic Ulcers — Ulcers of the stomach (gastric ulcer) and the first part of the small intestine (duodenal ulcer)
- Erosive Esophagitis — Inflammation and damage to the esophagus lining caused by stomach acid
- Functional Dyspepsia — Upper abdominal discomfort, bloating, early satiety, and nausea without a structural cause
- Nausea and Vomiting — Including nausea associated with GERD, gastroparesis, or post-meal discomfort
- Gastroparesis — Delayed stomach emptying causing bloating, fullness, and nausea
- Helicobacter pylori Eradication — As part of a combination therapy to treat H. pylori bacterial infections (along with antibiotics)
- Zollinger-Ellison Syndrome — A rare condition involving excessive acid production
How Does PABTOP-DSR Work?
How PABTOP-DSR Works – Simple Explanation :
Pantoprazole Sodium IP — As Gastro-resistant pellets
- PABTOP-DSR uses a two-pronged approach — reducing acid production while simultaneously improving the movement of food through the gut. Pantoprazole — The Proton Pump Inhibitor (PPI) Pantoprazole belongs to the class of Proton Pump Inhibitors (PPIs). The stomach produces acid through tiny pumps called proton pumps (H⁺/K⁺-ATPase enzymes) located in the stomach lining. Pantoprazole works by irreversibly blocking these proton pumps, dramatically reducing the amount of acid produced. This allows inflamed, ulcerated, or damaged tissues of the esophagus and stomach to heal, while also relieving burning and discomfort associated with excess acid. Because Pantoprazole is acid-sensitive, it is formulated as gastro-resistant (enteric-coated) pellets that pass through the stomach intact and are only dissolved and absorbed in the alkaline environment of the small intestine.
Domperidone IP — As Prolonged-release pellets
- Domperidone — The Prokinetic Agent Domperidone is a dopamine D2 receptor antagonist that works in the upper digestive tract to speed up gastric emptying. It promotes coordinated contractions of the stomach and upper intestine, helping food move more quickly from the stomach into the intestine. This reduces bloating, nausea, early satiety (feeling full too fast), and the backflow of stomach contents into the esophagus. As a prolonged-release formulation, Domperidone in PABTOP-DSR is released gradually over time for sustained and consistent relief throughout the day.
Excipients — —
- Together, Pantoprazole reduces acid at its source while Domperidone ensures proper stomach motility — addressing both the cause and the symptoms of acid-related gastrointestinal disorders.
Dosage & How to Take
- Dose: As directed by the Physician.
- Route: Oral (by mouth)
- General Guidance:
- Take PABTOP-DSR 30 to 60 minutes before the first meal of the day (usually breakfast) for optimal effectiveness.
- Swallow the capsule whole with a glass of water — do not crush, chew, or open the capsule. The pellets inside have special coatings that must remain intact.
- Take it at the same time each day.
- The usual duration of treatment ranges from 4 to 8 weeks, but your doctor will advise based on your condition.
- Important: Do not self-medicate or alter dosage without consulting your doctor.
Important: Dosage and duration are determined by your doctor based on your age, weight, and medical condition. Always follow your physician's instructions.
Possible Side Effects
PABTOP-DSR is generally well-tolerated. However, some patients may experience:
Common (may affect up to 1 in 10 people):
- Headache
- Diarrhoea or loose stools
- Nausea
- Flatulence (gas) or bloating
- Dry mouth
Less Common:
- Constipation
- Dizziness
- Skin rash or itching
- Increased liver enzymes (usually reversible)
- Menstrual irregularities (in women, with prolonged use)
Rare but Serious (seek immediate medical attention):
- Acute Kidney Injury — An important adverse drug reaction listed for this medicine. Seek immediate medical help if you notice decreased urination, swelling, or unusual fatigue
- Severe allergic reactions (swelling of face, lips, tongue, or throat; difficulty breathing)
- Muscle weakness or cramps (low magnesium — with long-term use)
- Irregular heartbeat (QT prolongation — rare, related to Domperidone)
- Clostridium difficile-associated diarrhoea (severe, persistent diarrhoea)
- Severe skin reactions (Stevens-Johnson Syndrome — extremely rare)
Precautions & Warnings
Before taking PABTOP-DSR, inform your doctor if you:
- Before taking PABTOP-DSR, inform your doctor if you:
- Have known allergy to Pantoprazole, Domperidone, or any benzimidazole drug
- Have liver or kidney disease
- Have a history of heart problems or irregular heartbeat (QT prolongation)
- Have low potassium or magnesium levels
- Are pregnant or planning to become pregnant
- Are breastfeeding (Domperidone may pass into breast milk)
- Are taking any medicines that affect the heart rhythm
Special Warnings:
- PABTOP-DSR should not be crushed or chewed — this destroys the protective pellet coatings
- Do not use for longer than prescribed without medical review — long-term use of PPIs requires monitoring
- Domperidone may rarely affect the heart's electrical activity (QT interval) — use with caution in patients with cardiac risk factors
- The medicine may mask symptoms of serious gastric conditions, including stomach cancer. Consult a doctor if symptoms persist or worsen
- Pregnancy and Lactation: Should not be used during pregnancy or breastfeeding unless considered safe by your doctor
Drug Interactions
Inform your doctor about all medications you are currently taking. PABTOP-DSR may interact with:
Always consult a healthcare professional before combining medications.
Storage Instructions
- Store protected from moisture
- Store at a temperature not exceeding 25°C
- Store in a cool, dry, and dark place
- Keep away from direct sunlight and heat
- Keep the medicine out of reach of children
- Do not use after the expiry date printed on the pack
Why Choose PABTOP-DSR?
- Dual-action formula — Acid reduction + improved gastric motility in one capsule
- DSR Technology — Gastro-resistant & prolonged-release pellets ensure targeted delivery
- Once-daily dosing — Convenient and improves patient compliance
- Comprehensive GI relief — Addresses both acid excess and digestive sluggishness
- WHO-GMP & ISO Approved manufacturing (DM Pharma Private Limited)
- Trusted formulation widely prescribed across India by gastroenterologists and general physicians
Frequently Asked Questions
Take it 30–60 minutes before your first meal of the day (preferably breakfast) for maximum acid-suppressing effect.
No. The capsule must be swallowed whole. Crushing or opening it destroys the special gastro-resistant coating on the pellets, making the medicine ineffective and potentially causing irritation.
Most patients notice improvement in symptoms within 2–3 days. Full healing of ulcers and esophagitis may take 4–8 weeks of regular use.
For occasional acidity, antacids are usually sufficient. PABTOP-DSR is a prescription medicine for chronic or more significant acid-related conditions. Always consult a doctor before use.
It should not be used during pregnancy unless your doctor has specifically prescribed it after weighing the benefits and risks.
Long-term PPI use should always be under a doctor's supervision. Your doctor will monitor for potential side effects like low magnesium and bone health changes.
It is advisable to avoid alcohol, as it can irritate the stomach lining and worsen acid reflux symptoms.